Session 5 | Computational Design and GPCR Therapeutics

Application of computational methods in rational design of multi-target ligands as potential antipsychotics and antidepressants
Katarina Nikolic, Belgrade (RS)

Integrated computational and structural approaches for GPCR drug discovery
Bryan Roth, Chapel Hill (US)

In Silico Hit Discovery for GPCRs across Scale and Sector
Brian Bender, Cambride (UK)

GPCR structure analysis platform and activation mechanisms
David Gloriam, Copenhagen (UK)

COFFEE BREAK

Session 6 | Molecular Structure and Dynamics

Structural insights into signal transduction of metabotropic glutamate receptors
Beili Wu, Shanghai (CN)

Structural insights into allostery in GPCRs: G proteins, arrestin and dimers
Christopher G. Tate, Cambride (UK)

Live-cell structural insights into arrestin interactions with a secretin-like GPCR
Irene Coin, Leipzig (DE)

A modular ligand-directed approach to label endogenous aminergic GPCRs in live cells
Xavier Gómez-Santacana, Montpellier (FR)

Poster Appetizer Session

Lunch & Poster Session

Session 6 | Molecular Structure and Dynamics

Structural insights into GPCR-beta-arrestin interaction and signaling
Arun A. Shukla, Kanpur (IN)

Structural and Mechanistic insights into class B1 GPCR signalling and allostery (Cryo-EM)
Denise Wootten, Victoria (AU)

Allosteric modulation of metabotropic glutamate receptor activation resolved by single molecule FRET using minimally invasive labeling strategies
Robert B. Quast, Montpellier (FR)

Structural and functional studies of CC chemokine receptor 5 phosphorylation and its interaction with arrestin2
Polina Isaikina, Basel (CH)

COFFEE BREAK

Keynote Lecture

The role of protein dynamics in GPCR signaling
Brian Kobilka, Stanford (US)

CRC Closing remarks & Farewell

Closing Party
Early Career Investigator Session and Awarding at Moritzbastei Leipzig