09:00–10:15
Keynote Lecture
Adhesion-GPCR signaling in synapse formation
Thomas C. Südhof, Stanford (US)
10:15–10:45
COFFEE BREAK
10:45–12:30
Session 4 | GPCR in Physiology and Disease
Orphan GPCRs in the vascular and immune system
Nina Wettschureck, Bad Nauheim (DE)
How come that GIPR agonists and antagonists both result in weight loss?
Mette Rosenkilde, Copenhagen (DK)
Oncomodulation explained: cancer going viral
Nick Bergkamp, Amsterdam (NL)
Structural and Functional Diversity Among Agonist-Bound States of the GLP-1 Receptor
Brian Cary, Madison (US)
An orphan GPCR as a novel regulator of adipose tissue function by a non-canonical mechanism – Implication in obesity and type 2 diabetes
Julie Dam, Paris (FR)
12:30–13:00
Lunch & Poster Session
13:15–14:00
Poster Session and Discussion
14:00–15:30
Session 4 | GPCR in Physiology and Disease
Targeting GPCRs to enhance haematopoietic stem cell transplantation
Michael Freissmuth, Vienna (AT)
Targeting GPCRs to treat metabolic disease
I. Sadaf Farooqi, Cambridge (UK)
A NanoBiT/BRET-based binding assay for CRISPR-Cas9-edited FZD7 allows real-time analysis of ligand binding in the colorectal cancer model
Pawel Kozielewicz, Solna (SE)
G protein-coupled receptor 84 is an evolutionary conserved Gα15-coupled immune cell receptor
Claudia Stäubert, Leipzig (DE)
15:30–16:15
COFFEE BREAK
16:15–18:00
Session 5 | Computational Design and GPCR Therapeutics
Partial agonism in the picture
Adriaan Ijzermann, Leiden (NL)
Variation in GPCR Signaling: Implications for Physiology and Drug Discovery
M. Madan Babu, Memphis (US)
Structure-Based Computer Driven Discovery of GPCR Ligands with New Chemotypes and Functional Selectivity
Vsevolod Katritch, Los Angeles (US)
Optical control of family A GPCRs using azobenzene-derived photoswitchable ligands
Rob Leurs, Amsterdam (NL)
Caenorhabditis elegans as model organism for GPCR research
Anette Kaiser, Leipzig (DE)
18:00–18:15
SHORT BREAK
18:15–18:45
Greetings & Poster Appetizer Session
18:45–21:00
Poster Session with Drinks and Snacks – funded by Stiftung Charité
